Hemophagocytic Syndrome Associated with Herpes Virus 8 and Multicentric Castleman Diseases in A HIV-Negative Patient

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Kaposi Sarcoma Herpes Virus-associated Hemophagocytic Syndrome Complicated by Multicentric Castleman Disease and Kaposi Sarcoma in a HIV-negative Immunocompetent Patient: An Autopsy Case

Kaposi sarcoma herpes virus (KSHV), also known as human herpesvirus-8, plays an important role in the pathogenesis of Kaposi sarcoma (KS), multicentric Castleman disease (MCD) of the plasma cell type, and primary effusion lymphoma. KSHV is rarely associated with the hemophagocytic syndrome (HPS), but when it does occur, it most occurs in immunocompromised patients. We report herein an unusual c...

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Complete remission in a patient with human herpes virus-8 negative multicentric Castleman disease using CHOP chemotherapy.

Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder. Although MCD pathogenesis is unclear, studies have suggested that human herpesvirus 8 (HHV-8) may be associated with the disorder. Recent reports have identified MCD cases without viral infection. A 43-year-old woman presented to our hospital for fever and myalgia of 6 months' duration. The complete blood count reveale...

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Intracavitary cidofovir for human herpes virus-8-associated primary effusion lymphoma in an HIV-negative patient.

Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that mainly occurs in immunodeficient patients and is associated with infection by human herpes virus-8 (HHV-8). It develops in serous cavities, causing lymphomatous effusions in the absence of lymphadenopathy or organomegaly.1,2 Previous studies suggested that PEL occurs almost exclusively in HIVinfected patients. It was fi...

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[Multicentric Castleman disease not associated with HHV-8 and HIV viruses].

Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease suggest an exaggerated response to antigenic stimuli seen in other diseases associat...

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Remission of HHV-8 and HIV-associated multicentric Castleman disease with ganciclovir treatment.

Multicentric Castleman disease (MCD) is a lymphoproliferative disorder associated with human herpesvirus 8 (HHV-8) infection among persons with human immunodeficiency virus (HIV) infection. Treatment often includes chemotherapy, and progression to non-Hodgkin lymphoma frequently occurs. MCD is characterized in part by active HHV-8 replication, and many of the symptoms of MCD may be attributable...

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ژورنال

عنوان ژورنال: Journal of Microbiology and Infectious Diseases

سال: 2017

ISSN: 2146-3158

DOI: 10.5799/jmid.369272